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Literature summary for 2.3.1.286 extracted from
- A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis (2017), Biochem. Biophys. Res. Commun., 493, 1204-1209 .
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Mycobacterium smegmatis mc2155 cells | Mycobacterium tuberculosis |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | 1 mM used in assay conditions | Mycobacterium tuberculosis |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-NTA column chromatography | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| [HU protein]-N6-acetyl-L-lysine + NAD+ + H2O | overall reaction | Mycobacterium tuberculosis | [HU protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Rv1151c | - |
Mycobacterium tuberculosis |
| Sir2 | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Mycobacterium tuberculosis | |
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Release 2023.1 (January 2023)
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