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Literature summary for 2.3.1.286 extracted from

  • Fang, M.; Guo, W.R.; Park, Y.; Kang, H.G.; Zarbl, H.
    Enhancement of NAD+-dependent SIRT1 deacetylase activity by methylselenocysteine resets the circadian clock in carcinogen-treated mammary epithelial cells (2015), Oncotarget, 6, 42879-42891.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Inhibitors

Inhibitors Comment Organism Structure
cambinol
-
 Homo sapiens
cambinol
-
 Rattus norvegicus
Ex257 specific inhibitor of isoform SIRT1 Homo sapiens
Ex257 specific inhibitor of isoform SIRT1 Rattus norvegicus
N-methyl-N-nitrosourea
-
 Homo sapiens
N-methyl-N-nitrosourea
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine Rattus norvegicus
-
 nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine Homo sapiens
-
 nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96EB6
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary epithelial cell
-
 Rattus norvegicus
-
mammary epithelial cell
-
 Homo sapiens
-
MCF-10A cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
-
 Rattus norvegicus nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
-
 Homo sapiens nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Rattus norvegicus
SIRT1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Rattus norvegicus
NAD+ dependent on Homo sapiens