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Literature summary for 2.3.1.286 extracted from

  • Lee, Y.H.; Chen, H.Y.; Su, L.J.; Chueh, P.J.
    Sirtuin 1 (SIRT1) deacetylase activity and NAD+/NADH ratio are imperative for capsaicin-mediated programmed cell death (2015), J. Agric. Food Chem., 63, 7361-7370.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-acyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96EB6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
fetus
-
 Homo sapiens
-
lung fetal lung cell Homo sapiens
-
MRC-5 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [protein]-N6-acyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
-
 Homo sapiens
sirtuin 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction SIRT1 depletion by RNA interference attenuates capsaicin-induced apoptosis in A-549 cancer cells and autophagy in MRC-5 cells Homo sapiens