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Literature summary for 2.3.1.286 extracted from

  • Yang, H.; Zhou, L.; Shi, Q.; Zhao, Y.; Lin, H.; Zhang, M.; Zhao, S.; Yang, Y.; Ling, Z.Q.; Guan, K.L.; Xiong, Y.; Ye, D.
    SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth (2015), EMBO J., 34, 1110-1125.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine Homo sapiens isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2 nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NTG7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2 Homo sapiens nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT3
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform SIRT3 expression is reduced in human pancreatic tumors down