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Literature summary for 2.3.1.286 extracted from

  • Bhalla, S.; Gordon, L.I.
    Functional characterization of NAD dependent de-acetylases SIRT1 and SIRT2 in B-cell chronic lymphocytic leukemia (CLL) (2016), Cancer Biol. Ther., 17, 300-309.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Inhibitors

Inhibitors Comment Organism Structure
EX-527
-
 Homo sapiens
sirtinol
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [protein]-N6-acyl-L-lysine Homo sapiens
-
 nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
B-cell
-
 Homo sapiens
-
B-cell chronic lymphocytic leukemia cell
-
 Homo sapiens
-
JVM-3 cell
-
 Homo sapiens
-
MEC-2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [protein]-N6-acyl-L-lysine
-
 Homo sapiens nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1 isoform Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NAD+ dependent on Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform SIRT1 mRNA is upregulated in chronic lymphocytic leukemia up

General Information

General Information Comment Organism
physiological function enzyme expression is crucial for the survival of the cell Homo sapiens