Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.286 extracted from

  • Schlicker, C.; Gertz, M.; Papatheodorou, P.; Kachholz, B.; Becker, C.F.; Steegborn, C.
    Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5 (2008), J. Mol. Biol., 382, 790-801.
    View publication on PubMed
Search for more literature for 2.3.1.286

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine Homo sapiens Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine Homo sapiens Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NTG7
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Sirt3 has almost no activity against acetylated cytochrome c Homo sapiens ?
-
 ?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase Homo sapiens nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine Sirt3 can deacetylate and activate isocitrate dehydrogenase 2, an enzyme that promotes regeneration of antioxidants and catalyzes a key regulation point of the citric acid cycle Homo sapiens nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT3
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme can regulate flux and anapleurosis of this central metabolic cycle Homo sapiens