Literature summary for 2.3.1.286 extracted from

Asher, G.; Gatfield, D.; Stratmann, M.; Reinke, H.; Dibner, C.; Kreppel, F.; Mostoslavsky, R.; Alt, F.W.; Schibler, U.
SIRT1 regulates circadian clock gene expression through PER2 deacetylation (2008), Cell, 134, 317-328.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NAD+ + [PER2 protein]-N6-acetyl-L-lysine	Homo sapiens	SIRT1 regulates circadian clock gene expression through PER2 deacetylation	nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q96EB6	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NAD+ + [PER2 protein]-N6-acetyl-L-lysine	-	Homo sapiens	nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?
NAD+ + [PER2 protein]-N6-acetyl-L-lysine	SIRT1 regulates circadian clock gene expression through PER2 deacetylation	Homo sapiens	nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose	-	?

Synonyms

Synonyms	Comment	Organism
SIRT1	-	Homo sapiens

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Release 2023.1 (January 2023)