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Literature summary for 2.3.1.286 extracted from

  • Madabushi, A.; Hwang, B.J.; Jin, J.; Lu, A.L.
    Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase (2013), Biochem. J., 456, 89-98.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
SIRT1-FL (full-length human SIRT1) is cloned in the pECE vector (clone 1791) and N-terminally truncated SIRT1 (SIRT1-NT with residues 7–83 deleted) cloned in the pCDNA3.1 vector. To express the FLAGtagged hSIRT1 (human SIRT1) proteins, the hSIRT1 constructs are transfected into HEK (human embryonic kidney)-293T cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine Homo sapiens deacetylation and stimulation of the thymine DNA glycosylase activity by SIRT1 enhances DNA demethylation nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
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 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q96EB6
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-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
-
 Homo sapiens nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine deacetylation and stimulation of the thymine DNA glycosylase activity by SIRT1 enhances DNA demethylation Homo sapiens nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT1
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 Homo sapiens