Literature summary for 2.3.1.281 extracted from

Pawlik, K.; Kotowska, M.; Chater, K.; Kuczek, K.; Takano, E.
A cryptic type I polyketide synthase (cpk) gene cluster in Streptomyces coelicolor A3(2) (2007), Arch. Microbiol., 187, 87-99 .

Search for more literature for 2.3.1.281

Organism

Organism	UniProt	Comment	Textmining
Streptomyces coelicolor	Q9L8J0	cluster gene, contains subunit genes cpkA, cpkB and cpkC	-
Streptomyces coelicolor A3(2)	Q9L8J0	cluster gene, contains subunit genes cpkA, cpkB and cpkC	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6 malonyl-CoA + 5 NADPH + NADH + 6 H+	-	Streptomyces coelicolor	(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O	-	?
6 malonyl-CoA + 5 NADPH + NADH + 6 H+	-	Streptomyces coelicolor A3(2)	(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP+ + NAD+ + 6 CO2 + 4 H2O	-	?

Expression

Organism	Comment	Expression
Streptomyces coelicolor	polyketide synthase is expressed in transition phase	additional information

General Information

General Information	Comment	Organism
physiological function	the synthase consists of a loading module, five extension modules and a reductase as a terminal domain instead of a typical thioesterase. All acyltransferase domains are specific for a malonyl extender, and have a B-type ketoreductase. A gene disruption mutant does not exhibit any morphological, growth or antibiotic production (actinorhodin and undecyloprodigiosin) differences compared to the wild type, and no difference in antibacterial activity is observed as well as in the UV-Vis absorbance	Streptomyces coelicolor

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)