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Literature summary for 2.3.1.262 extracted from

  • Prothiwa, M.; Englmaier, F.; Boettcher, T.
    Competitive live-cell profiling strategy for discovering inhibitors of the quinolone biosynthesis of Pseudomonas aeruginosa (2018), J. Am. Chem. Soc., 140, 14019-14023 .
    View publication on PubMed
Search for more literature for 2.3.1.262

Protein Variants

Protein Variants Comment Organism
additional information development of a competitive in situ labeling strategy using an electrophilic activity-based probe and target protein expressing Escherichia coli cells Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
1-(1-aminonaphthalen-2-yl)-2-chloroethan-1-one strong inhibition Pseudomonas aeruginosa
1-(2-aminophenyl)-2-chloroethan-1-one strong inhibition Pseudomonas aeruginosa
1-(7-amino-2,3-dihydro-1,4-benzodioxin-6-yl)-2-chloroethan-1-one strong inhibition Pseudomonas aeruginosa
2-bromo-1-(pyridin-2-yl)ethan-1-one slight inhibition Pseudomonas aeruginosa
2-chloro-1-(1H-indol-7-yl)ethan-1-one strong inhibition Pseudomonas aeruginosa
2-chloro-1-(2,4-difluorophenyl)ethan-1-one strong inhibition Pseudomonas aeruginosa
2-chloro-1-phenylethan-1-one strong inhibition Pseudomonas aeruginosa
2-chloro-N-(3-chloro-2-methylphenyl)acetamide strong inhibition Pseudomonas aeruginosa
2-chloro-N-(4-methylphenyl)acetamide
-
 Pseudomonas aeruginosa
3,5-dichloro-N-(1-chloro-3-methyl-2-oxopentan-3-yl)-4-methylbenzamide
-
 Pseudomonas aeruginosa
3-chlorobicyclo[2.2.1]heptan-2-one slight inhibition Pseudomonas aeruginosa
additional information inhibitor development targeting enzyme PqsD, development of a competitive in situ labeling strategy using an electrophilic activity-based probe and target protein expressing Escherichia coli cells Pseudomonas aeruginosa
N-(butoxymethyl)-2-chloro-N-(2,6-diethylphenyl)acetamide
-
 Pseudomonas aeruginosa
tert-butyl chloroacetate
-
 Pseudomonas aeruginosa
[4-(2-chloropropanoyl)phenyl]acetic acid slight inhibition Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa P20582
-
-
Pseudomonas aeruginosa 1C P20582
-
-
Pseudomonas aeruginosa ATCC 15692 P20582
-
-
Pseudomonas aeruginosa CIP 104116 P20582
-
-
Pseudomonas aeruginosa DSM 22644 P20582
-
-
Pseudomonas aeruginosa JCM 14847 P20582
-
-
Pseudomonas aeruginosa LMG 12228 P20582
-
-
Pseudomonas aeruginosa PRS 101 P20582
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa ATCC 15692 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa 1C 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa PRS 101 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa DSM 22644 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa CIP 104116 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa LMG 12228 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?
anthraniloyl-CoA + malonyl-CoA
-
 Pseudomonas aeruginosa JCM 14847 2-aminobenzoylacetyl-CoA + CoA + CO2
-
 ?

Synonyms

Synonyms Comment Organism
2-heptyl-4(1H)-quinolone synthase UniProt Pseudomonas aeruginosa
PqsD
-
 Pseudomonas aeruginosa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Pseudomonas aeruginosa

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0012
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 1-(1-aminonaphthalen-2-yl)-2-chloroethan-1-one
0.0013
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 2-chloro-1-(2,4-difluorophenyl)ethan-1-one
0.0018
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 2-chloro-1-phenylethan-1-one
0.0019
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 1-(2-aminophenyl)-2-chloroethan-1-one
0.0021
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 2-chloro-N-(3-chloro-2-methylphenyl)acetamide
0.0022
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 1-(7-amino-2,3-dihydro-1,4-benzodioxin-6-yl)-2-chloroethan-1-one
0.0025
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 2-chloro-1-(1H-indol-7-yl)ethan-1-one
0.155
-
 pH not specified in the publication, 37°C Pseudomonas aeruginosa 2-chloro-N-(4-methylphenyl)acetamide