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Literature summary for 2.3.1.26 extracted from

  • Iwasaki, A.; Tadenuma, T.; Sumimoto, S.; Ohshiro, T.; Ozaki, K.; Kobayashi, K.; Teruya, T.; Tomoda, H.; Suenaga, K.
    Biseokeaniamides A, B, and C, sterol O-Acyltransferase inhibitors from an Okeania sp. marine cyanobacterium (2017), J. Nat. Prod., 80, 1161-1166 .
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
biseokeaniamide A
-
 Homo sapiens
biseokeaniamide B exhibits moderate cytotoxicity against HeLa cancer cells; exhibits moderate cytotoxicity against HeLa cancer cells Homo sapiens
biseokeaniamide C
-
 Homo sapiens
purpactin A
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O75908 isoform SOAT2
-
Homo sapiens P35610 isoform SOAT1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol oleate
-
 ?

Synonyms

Synonyms Comment Organism
SOAT!
-
 Homo sapiens
Soat2
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0009
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
0.000918
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
0.0013
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
0.0015
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
0.0018
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
0.0018
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
0.0025
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens purpactin A
0.0025
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
0.0068
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
0.0069
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
0.0096
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide A
0.0099
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide B
0.011
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
0.012
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
0.032
-
 enzyme-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C
0.096
-
 cell-based assay, 37°C, pH not specified in the publication Homo sapiens biseokeaniamide C