Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.26 extracted from

  • Ohshiro, T.; Seki, R.; Fukuda, T.; Uchida, R.; Tomoda, H.
    Celludinones, new inhibitors of sterol O-acyltransferase, produced by Talaromyces cellulolyticus BF-0307 (2018), J. Antibiot., 71, 1000-1007 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in CHO cells Homo sapiens
expression in CHO cells Chlorocebus aethiops

Inhibitors

Inhibitors Comment Organism Structure
celludinone A1 an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay; an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay Chlorocebus aethiops
celludinone A1 an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay; an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay Homo sapiens
celludinone A2 an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay; an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay Chlorocebus aethiops
celludinone A2 an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay; an indanone produced by Talaromyces cellulolyticus BF-0307, inhibits the sterol O-acyltransferase 1 and 2 isozymes in a cell-based assay Homo sapiens
celludinone B an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform; an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform Chlorocebus aethiops
celludinone B an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform; an indanone produced by Talaromyces cellulolyticus BF-0307, selectively inhibits the SOAT2 isoform Homo sapiens
FD-549 benzophenone inhibitor; benzophenone inhibitor Chlorocebus aethiops
FD-549 benzophenone inhibitor; benzophenone inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Chlorocebus aethiops O77759 isoform SOAT2
-
Chlorocebus aethiops O77760 isoform SOAT1
-
Homo sapiens O75908
-
-
Homo sapiens P35610
-
-

Synonyms

Synonyms Comment Organism
Soat2
-
Chlorocebus aethiops

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000069
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone B
0.00015
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone B
0.00068
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens FD-549
0.00091
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops FD-549
0.0028
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone B
0.0029
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone B
0.0048
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone A1
0.0052
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens FD-549
0.0061
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone A2
0.008
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone A1
0.0088
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone A1
0.0099
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops FD-549
0.012
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone A1
0.013
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone A2
0.015
-
cell-based assay, 37°C, pH not specified in the publication Homo sapiens celludinone A2
0.015
-
cell-based assay, 37°C, pH not specified in the publication Chlorocebus aethiops celludinone A2