Literature summary for 2.3.1.26 extracted from

Shibuya, K.; Kawamine, K.; Miura, T.; Ozaki, C.; Edano, T.; Mizuno, K.; Yoshinaka, Y.; Tsunenari, Y.
Design, synthesis and pharmacology of aortic-selective acyl-CoA Cholesterol O-acyltransferase (ACAT/SOAT) inhibitors (2018), Bioorg. Med. Chem., 26, 4001-4013 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
9-(benzo[d]oxazol-2-ylthio)-N-(2,6-diisopropylphenyl)-nonanamide	inhibitor obtained by combination of weak inhibitors N-(2,6-diisopropylphenyl)and 2-(methylthio)benzo[d]oxazole. At doses of 1 and 3 mg/kg, compound significantly decreases the lipid-accumulation areas in the aortic arch to 74 and 69%, respectively without reducing the plasma total cholesterol level in high fat- and cholesterol-fed F1B hamsters	Oryctolagus cuniculus

Organism

Organism	UniProt	Comment	Textmining
Oryctolagus cuniculus	G1SUQ0	-	-

Synonyms

Synonyms	Comment	Organism
ACAT	-	Oryctolagus cuniculus
Soat1	-	Oryctolagus cuniculus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000004	-	aortic microsomes, pH 7.4, 37°C	Oryctolagus cuniculus	9-(benzo[d]oxazol-2-ylthio)-N-(2,6-diisopropylphenyl)-nonanamide

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Release 2023.1 (January 2023)