Application | Comment | Organism |
---|---|---|
drug development | the enzyme is regarded as a potential therapeutic target for cardiovascular diseases | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | - |
Homo sapiens | |
2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | - |
Homo sapiens | |
2-[(5aS,6S,8S,9aS)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | - |
Homo sapiens | |
2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | - |
Homo sapiens | |
2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | - |
Homo sapiens | |
additional information | design and synthesis of simple, potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2), overview. Natural product pyripyropene A (PPPA) and its analogues are the only chemical type ACAT2-specific inhibitors and are isolated from the fungal strain Aspergillus fumigatus strain FO-12897 | Homo sapiens | |
pyripyropene A | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | Homo sapiens | - |
CoA + cholesterol ester | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + cholesterol | - |
Homo sapiens | CoA + cholesterol ester | - |
? | |
additional information | NBD22-steryl ester fluorescence assay | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACAT2 | - |
Homo sapiens |
cholesterol acyltransferase 2 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000077 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.000155 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aS,6S,8S,9aS)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.000185 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | pyripyropene A | |
0.000416 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.000743 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.001272 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aS,6S,8S,9aS,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.0017 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aR,6R,8R,9aR,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.001789 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.002456 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aR,6R,8R,9aR,10S)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate | |
0.003059 | - |
isozyme ACAT2, pH and temperature not specified in the publication | Homo sapiens | 2-[(5aS,6S,8S,9aS,10R)-6-(acetyloxy)-10-hydroxy-5a-methyl-1-oxo-3-(pyridin-3-yl)-6,7,8,9,9a,10-hexahydro-1H,5aH-pyrano[4,3-b][1]benzopyran-8-yl]-2-methylpropane-1,3-diyl diacetate |
General Information | Comment | Organism |
---|---|---|
physiological function | isozyme ACAT2 is responsible for absorption of dietary cholesterol from the intestine and lipoprotein production by the liver, the steryl esters catalyzed by ACAT2 can incorporate into both intracellular lipid droplets and extracellular lipoproteins | Homo sapiens |