Application | Comment | Organism |
---|---|---|
drug development | the enzyme is a potential target for treating hypercholesterolemia | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene ACAT2, genotying, sequence comparison and phylogenetic analysis, two human ACAT2 gene polymorphisms have significant effects on 41A-G (Glu14Gly, rs9658625) and 734C-T (Thr254Ile, rs2272296), on plasma lipid levels and coronary artery disease susceptibility, recombinant expression of wild-tpe and mutant enzymes in ACAT-deficient AC-29 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E14G | naturally occuring polymorphism, the enzymatic activity of the mutant is approximately two times higher than the wild-type activity | Homo sapiens |
T254I | naturally occuring polymorphism, the mutant shows enzyme the same enzyme activity as the wild-type | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75908 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ACAT2 | - |
Homo sapiens |
acyl-coenzyme A:cholesterol acyltransferase 2 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
additional information | two human ACAT2 gene polymorphisms have significant effects on 41A-G (Glu14Gly, rs9658625) and 734C-T (Thr254Ile, rs2272296), on plasma lipid levels and coronary artery disease susceptibility | Homo sapiens |
physiological function | the enzyme plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids | Homo sapiens |