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Literature summary for 2.3.1.26 extracted from
- Docosahexaenoic acid is a substrate for ACAT1 and inhibits cholesteryl ester formation from oleic acid in MCF-10A cells (2009), Prostaglandins Leukot. Essent. Fatty Acids, 80, 165-171.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid | - |
Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| MCF-10A cell | primary isoform expressed is ACAT1 | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| docosahexaenoyl-CoA + cholesterol | rate of cholesteryl ester formation is faster and more cholesteryl ester is formed with oleic acid compared to docosahexanoic acid. Docosahexanoic acid substantially reduces cholesteryl ester formation when given in combination with oleic acid | Homo sapiens | CoA + cholesteryl docosahexaenoate | - |
? | |
| oleoyl-CoA + cholesterol | rate of cholesteryl ester formation is faster and more cholesteryl ester is formed with oleic acid compared to docosahexanoic acid. Docosahexanoic acid substantially reduces cholesteryl ester formation when given in combination with oleic acid | Homo sapiens | CoA + cholesteryl oleate | - |
? | |
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