Literature summary for 2.3.1.26 extracted from

Sakai, K.; Ohte, S.; Ohshiro, T.; Matsuda, D.; Masuma, R.; Rudel, L.L.; Tomoda, H.
Selective inhibition of acyl-CoA:cholesterol acyltransferase 2 isozyme by flavasperone and sterigmatocystin from Aspergillus species (2008), J. Antibiot., 61, 568-572.

Search for more literature for 2.3.1.26

Cloned(Commentary)

Cloned (Comment)	Organism
expression of isoforms ACAT1 and ACAT2 in CHO cell	Chlorocebus aethiops

Inhibitors

Inhibitors	Comment	Organism	Structure
aurasperone A	isolation from the culture broth of Aspergillus species; isolation from the culture broth of Aspergillus species	Chlorocebus aethiops
aurasperone D	isolation from the culture broth of Aspergillus species; isolation from the culture broth of Aspergillus species	Chlorocebus aethiops
averufanin	isolation from the culture broth of Aspergillus species; isolation from the culture broth of Aspergillus species	Chlorocebus aethiops
flavasperone	isolation from the culture broth of Aspergillus species, selective for isoform ACAT2	Chlorocebus aethiops
sterigmatocystin	isolation from the culture broth of Aspergillus species, selective for isoform ACAT2	Chlorocebus aethiops

Organism

Organism	UniProt	Comment	Textmining
Chlorocebus aethiops	O77759	isoform ACAT2	-
Chlorocebus aethiops	O77760	isoform ACAT1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0015	-	isoform ACAT2, 37°C, cell-based assay	Chlorocebus aethiops	aurasperone A
0.0015	-	isoform ACAT2, 37°C, cell-based assay	Chlorocebus aethiops	aurasperone D
0.0024	-	isoform ACAT2, 37°C, cell-based assay	Chlorocebus aethiops	sterigmatocystin
0.006	-	isoform ACAT1, 37°C, cell-based assay	Chlorocebus aethiops	aurasperone A
0.006	-	isoform ACAT2, 37°C, cell-based assay	Chlorocebus aethiops	flavasperone
0.007	-	isoform ACAT1, 37°C, cell-based assay	Chlorocebus aethiops	aurasperone D
0.012	-	isoform ACAT2, 37°C, cell-based assay	Chlorocebus aethiops	averufanin
0.0218	-	isoform ACAT1, 37°C, cell-based assay	Chlorocebus aethiops	averufanin
0.03	-	isoform ACAT1, 37°C, cell-based assay	Chlorocebus aethiops	sterigmatocystin

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Release 2023.1 (January 2023)