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Literature summary for 2.3.1.26 extracted from

  • Miike, T.; Shirahase, H.; Jino, H.; Kunishiro, K.; Kanda, M.; Kurahashi, K.
    Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells (2008), Life Sci., 82, 79-84.
    View publication on PubMed

Application

Application Comment Organism
medicine an anti-oxidative ACAT inhibitor or the combination of an antioxidant and an ACAT inhibitor protects foam cells from oxidative stress and effectively reduces cholesterol levels, which would be a promising approach in anti-atherosclerotic therapy Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
N-(4,6-dimethyl-1-pentylindolin-7-yl)-2,2-dimethylpropanamide KY-455, an anti-oxidative ACAT inhibitor Homo sapiens
YM-750
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Homo sapiens
-
CoA + cholesterol ester
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
THP-1 cell THP-1 cell-derived foam cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
Homo sapiens CoA + cholesterol ester
-
?

Synonyms

Synonyms Comment Organism
ACAT
-
Homo sapiens
acyl-CoA:cholesterol acyltransferase
-
Homo sapiens