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Literature summary for 2.3.1.26 extracted from

  • Takahashi, K.; Kasai, M.; Ohta, M.; Shoji, Y.; Kunishiro, K.; Kanda, M.; Kurahashi, K.; Shirahase, H.
    Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid (2008), J. Med. Chem., 51, 4823-4833.
    View publication on PubMed
Search for more literature for 2.3.1.26

Inhibitors

Inhibitors Comment Organism Structure
[7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate pactimibe sulfate Oryctolagus cuniculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Oryctolagus cuniculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + cholesterol Oryctolagus cuniculus
-
 CoA + cholesterol ester
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
microsomes are prepared Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Oryctolagus cuniculus
-
intestinal mucosa
-
 Oryctolagus cuniculus
-
liver
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Oryctolagus cuniculus CoA + cholesterol ester
-
 ?
oleoyl-CoA + cholesterol activity assay Oryctolagus cuniculus ?
-
 ?

Synonyms

Synonyms Comment Organism
ACAT
-
 Oryctolagus cuniculus
acyl-CoA:cholesterol acyltransferase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 activity assay Oryctolagus cuniculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00069
-
 hepatic ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
0.00072
-
 intestinal ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
0.0019
-
 macrophage ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate
0.0159
-
 adrenal ACAT Oryctolagus cuniculus [7-(2,2-dimethylpropanamido)-4,6-dimethyl-1-octylindolin-5-yl]acetic acid hemisulfate