Literature summary for 2.3.1.26 extracted from

Bell, T.A.; Brown, J.M.; Graham, M.J.; Lemonidis, K.M.; Crooke, R.M.; Rudel, L.L.
Liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 with antisense oligonucleotides limits atherosclerosis development in apolipoprotein B100-only low-density lipoprotein receptor-/- mice (2006), Arterioscler. Thromb. Vasc. Biol., 26, 1814-1820.

Search for more literature for 2.3.1.26

Application

Application	Comment	Organism
medicine	hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins, and therapeutic interventions, such as the ACAT2-specific antisense oligonucleotide used here, which reduce acyltransferase 2 (ACAT2) function in the liver without affecting ACAT1, may provide clinical benefit for cardiovascular disease prevention	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88908	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	hepatic ACAT2 plays a critical role in driving the production of atherogenic lipoproteins	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
acyl-coenzyme A:cholesterol acyltransferase 2	-	Mus musculus

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Release 2023.1 (January 2023)