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Literature summary for 2.3.1.26 extracted from
- Properties of acyl-CoA:cholesterol O-acyltransferase in aortic microsomes from atherosclerotic rabbits (1980), Biochim. Biophys. Acta, 617, 458-471.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| albumin | - |
Rattus norvegicus | |
| albumin | stimulates | Oryctolagus cuniculus | |
| cholesterol | exogenous, not stimulatory | Oryctolagus cuniculus |  |
| cholesterol | exogenous, 25% increase of adrenal microsome activity and 2fold increase of activity in liver | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | inhibits at high concentrations | Oryctolagus cuniculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | submicrosomal distribution | Rattus norvegicus | - |
- |
| microsome | submicrosomal distribution | Oryctolagus cuniculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adrenal gland | - |
Rattus norvegicus | - |
| adrenal gland | - |
Oryctolagus cuniculus | - |
| aorta | - |
Rattus norvegicus | - |
| aorta | atheroschlerotic tissue | Oryctolagus cuniculus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Oryctolagus cuniculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
| additional information | - |
enhancement of activity following 8-11 weeks of cholesterol feeding | Oryctolagus cuniculus |
| 0.0001042 | - |
aortic microsomal preparation | Oryctolagus cuniculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesterol ester | - |
? | |
| acyl-CoA + cholesterol | - |
Oryctolagus cuniculus | CoA + cholesterol ester | - |
? | |
| oleoyl-CoA + cholesterol | - |
Rattus norvegicus | CoA + cholesteryl oleate | - |
? | |
| oleoyl-CoA + cholesterol | - |
Oryctolagus cuniculus | CoA + cholesteryl oleate | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
| 37 | - |
assay at | Oryctolagus cuniculus |
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Release 2023.1 (January 2023)
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