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Literature summary for 2.3.1.26 extracted from

  • Helgerud, P.; Saarem, K.; Norum, K.R.
    Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction (1981), J. Lipid Res., 22, 271-277.
    View publication on PubMed
Search for more literature for 2.3.1.26

Activating Compound

Activating Compound Comment Organism Structure
albumin stimulates, effect is dependent on oleoyl-CoA concentration Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
long-chain fatty acyl-CoA + cholesterol Homo sapiens the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption CoA + cholesteryl long-chain fatty acyl ester
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
duodenum
-
 Homo sapiens
-
ileum
-
 Homo sapiens
-
jejunum microsomal preparation, highest activity Homo sapiens
-
small intestine mucosa
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00005
-
 whole homogenate of biopsies from distal duodenum-proximal jejunum Homo sapiens
0.000053
-
 microsomal preparations from ileum, mean value Homo sapiens
0.000062
-
 microsomal preparations from duodenum, mean value Homo sapiens
0.00021
-
 microsomal preparations from jejunum, mean value Homo sapiens

Storage Stability

Storage Stability Organism
-70°C, biopsies, potassium phosphate buffer, stable for at least 3 years Homo sapiens
-70°C, microsomal preparations, stable for up to 1.5 years Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesterol ester
-
 ?
long-chain fatty acyl-CoA + cholesterol the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption Homo sapiens CoA + cholesteryl long-chain fatty acyl ester
-
 ?
oleoyl-CoA + cholesterol
-
 Homo sapiens CoA + cholesteryl oleate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.4 pH 6.5: 55% of activity maximum, pH 8.4: 75% of activity maximum Homo sapiens