Cloned (Comment) | Organism |
---|---|
gene NAA40, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + N-terminal-L-seryl1-[histone H2A] | Homo sapiens | - |
N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA | - |
? | |
acetyl-CoA + N-terminal-L-seryl1-[histone H4] | Homo sapiens | - |
N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q86UY6 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | increase in hNAA40 and a decrease in NAMPT and SIRT-1 expression in PBMC from drugnaive obese type 2 diabetes mellitus (T2DM) persons | Homo sapiens | - |
peripheral blood mononuclear cell | PBMC | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + N-terminal-L-seryl1-[histone H2A] | - |
Homo sapiens | N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA | - |
? | |
acetyl-CoA + N-terminal-L-seryl1-[histone H4] | - |
Homo sapiens | N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hNAA40 | - |
Homo sapiens |
N-alpha-acetyltransferase 40 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
acetyl-CoA | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake | down |
Homo sapiens | increase in hNAA40 and a decrease in NAMPT and SIRT-1 expression in PBMC from drugnaive obese type 2 diabetes mellitus (T2DM) persons. Metformin treatment reverts hNAA40, NAMPT, and SIRT-1 expression levels to normal levels. Glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake. Lipid intake results in an increase in expression of hNAA40 at 2 h post intake and a return to normal levels at 3 h | up |
General Information | Comment | Organism |
---|---|---|
metabolism | enzymes N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent protein deacetylase sirtuin-1 (SIRT-1) have been shown to exert important biological processes, including stress response and aging. The hNAA40, NAMPT, and SIRT-1 pathway might play a role in the determination of the healthy life-span. Metformin modulates this pathway | Homo sapiens |