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Literature summary for 2.3.1.257 extracted from

  • Alshahrani, A.; AlDubayee, M.; Zahra, M.; Alsebayel, F.M.; Alammari, N.; Alsudairy, F.; Almajed, M.; Aljada, A.
    Differential expression of human N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT) and sirtuin-1 (SIRT-1) pathway in obesity and T2DM modulation by Mmetformin and macronutrient intake (2019), Diabetes, 12, 2765-2774 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene NAA40, quantitative real-time PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + N-terminal-L-seryl1-[histone H2A] Homo sapiens
-
N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H4] Homo sapiens
-
N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q86UY6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information increase in hNAA40 and a decrease in NAMPT and SIRT-1 expression in PBMC from drugnaive obese type 2 diabetes mellitus (T2DM) persons Homo sapiens
-
peripheral blood mononuclear cell PBMC Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + N-terminal-L-seryl1-[histone H2A]
-
Homo sapiens N-terminal-Nalpha-acetyl-L-seryl1-[histone H2A] + CoA
-
?
acetyl-CoA + N-terminal-L-seryl1-[histone H4]
-
Homo sapiens N-terminal-Nalpha-acetyl-L-seryl1-[histone H4] + CoA
-
?

Synonyms

Synonyms Comment Organism
hNAA40
-
Homo sapiens
N-alpha-acetyltransferase 40
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake down
Homo sapiens increase in hNAA40 and a decrease in NAMPT and SIRT-1 expression in PBMC from drugnaive obese type 2 diabetes mellitus (T2DM) persons. Metformin treatment reverts hNAA40, NAMPT, and SIRT-1 expression levels to normal levels. Glucose intake results in a significant increase in expression of hNAA40 at 1 h and a significant decrease at 3 h post intake. Lipid intake results in an increase in expression of hNAA40 at 2 h post intake and a return to normal levels at 3 h up

General Information

General Information Comment Organism
metabolism enzymes N-alpha-acetyltransferase 40 (hNAA40), nicotinamide phosphoribosyltransferase (NAMPT), and NAD-dependent protein deacetylase sirtuin-1 (SIRT-1) have been shown to exert important biological processes, including stress response and aging. The hNAA40, NAMPT, and SIRT-1 pathway might play a role in the determination of the healthy life-span. Metformin modulates this pathway Homo sapiens