BRENDA - Enzyme Database
show all sequences of 2.3.1.255

The biological functions of Naa10 - From amino-terminal acetylation to human disease

Doerfel, M.J.; Lyon, G.J.; Gene 567, 103-131 (2015)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
the enzyme is associated with Ogden syndrome
Homo sapiens
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
nucleus
-
Homo sapiens
5634
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
26000
-
-
Homo sapiens
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
P41227
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HeLa cell
-
Homo sapiens
-
HT-1080 cell
-
Homo sapiens
-
U2OS cell
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
Naa10 undergoes autoacetylation at lysine K136
740508
Homo sapiens
?
-
-
-
-
Subunits
Subunits
Commentary
Organism
?
x * 26000, calculated from amino acid sequence
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
the enzyme is associated with Ogden syndrome
Homo sapiens
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
nucleus
-
Homo sapiens
5634
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
26000
-
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HeLa cell
-
Homo sapiens
-
HT-1080 cell
-
Homo sapiens
-
U2OS cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
additional information
Naa10 undergoes autoacetylation at lysine K136
740508
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 26000, calculated from amino acid sequence
Homo sapiens
Expression
Organism
Commentary
Expression
Homo sapiens
the expression of Naa10 increases during neuronal dendritic development of cerebellar Purkinje cells
up
General Information
General Information
Commentary
Organism
malfunction
knockdown of Naa10 in HeLa cells leads to apoptosis and sensitizes cells for daunorubicin-induced apoptosis
Homo sapiens
metabolism
Naa10 activates and/or amplifies the transcriptional activity of beta-catenin/TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21WAF1/CIP1 and promoting the G1/S cell cycle transition. Naa10 is essential for the activation of caspase-2/-3/-7 and -9 in HeLa cells after doxorubicin stimulation
Homo sapiens
General Information (protein specific)
General Information
Commentary
Organism
malfunction
knockdown of Naa10 in HeLa cells leads to apoptosis and sensitizes cells for daunorubicin-induced apoptosis
Homo sapiens
metabolism
Naa10 activates and/or amplifies the transcriptional activity of beta-catenin/TCF transcriptional activity thereby stimulating cyclin D1 and c-Myc expression leading to inhibition of p21WAF1/CIP1 and promoting the G1/S cell cycle transition. Naa10 is essential for the activation of caspase-2/-3/-7 and -9 in HeLa cells after doxorubicin stimulation
Homo sapiens
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
the expression of Naa10 increases during neuronal dendritic development of cerebellar Purkinje cells
up
Other publictions for EC 2.3.1.255
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
736506
Magin
The N-terminal acetyltransfera ...
Homo sapiens
J. Biol. Chem.
291
5270-5277
2016
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14
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741089
DePaolo
Acetylation of androgen recept ...
Mus musculus
Oncotarget
7
71417-71428
2016
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730955
Chang
Structural basis for substrate ...
Saccharolobus solfataricus
Sci. Rep.
5
8673
2015
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1
3
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4
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3
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4
4
735797
Ree
The N-terminal acetyltransfera ...
Danio rerio
Biosci. Rep.
35
e00249
2015
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1
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-
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4
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1
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1
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4
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9
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1
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4
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9
-
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2
2
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736273
Seo
Different subcellular localiza ...
Homo sapiens
Int. J. Oncol.
46
701-707
2015
-
-
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1
1
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736487
Eiyama
Protein N-terminal acetylation ...
Saccharomyces cerevisiae
J. Biol. Chem.
290
25034-25044
2015
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740508
Doerfel
The biological functions of Na ...
Homo sapiens
Gene
567
103-131
2015
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1
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2
1
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741085
Myklebust
Naa10 in development and disea ...
Homo sapiens
Oncotarget
6
34041-34042
2015
-
-
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1
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1
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1
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1
1
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-
741164
Xu
Two N-terminal acetyltransfera ...
Arabidopsis thaliana
Plant Cell
27
1547-1562
2015
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1
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1
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741046
Yoon
NAA10 controls osteoblast diff ...
Mus musculus
Nat. Commun.
5
5176
2014
-
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1
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1
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736866
Liszczak
Molecular basis for N-terminal ...
Schizosaccharomyces pombe
Nat. Struct. Mol. Biol.
20
1098-1105
2013
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1
20
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2
17
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1
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1
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16
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2
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1
20
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2
2
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17
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1
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16
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740179
Wan
Nalpha-acetyltransferase NatA ...
Saccharomyces cerevisiae
Biosci. Biotechnol. Biochem.
77
631-638
2013
-
-
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1
1
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719333
Wang
Drosophila variable nurse cell ...
Drosophila melanogaster
Dev. Dyn.
239
2813-2827
2010
-
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1
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1
1
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720453
Arnesen
The chaperone-like protein HYP ...
Homo sapiens
Mol. Cell. Biol.
30
1898-1909
2010
-
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1
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2
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3
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1
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1
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2
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5
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1
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1
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1
1
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1
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5
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1
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1
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702871
Arnesen
A novel human NatA Nalpha-term ...
Homo sapiens
BMC Biochem.
10
15
2009
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1
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1
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2
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1
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4
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1
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21
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1
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1
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1
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1
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1
1
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21
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1
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1
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705613
Pezza
The NatA acetyltransferase cou ...
Saccharomyces cerevisiae
Mol. Biol. Cell
20
1068-1080
2009
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1
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1
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3
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1
1
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703852
Ohkawa
N-acetyltransferase ARD1-NAT1 ...
Mus musculus
Genes Cells
13
1171-1183
2008
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1
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2
1
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706924
Perrot
Sequence requirements for Nalp ...
Saccharomyces cerevisiae
Yeast
25
513-527
2008
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1
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19
1
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740340
Arnesen
The protein acetyltransferase ...
Homo sapiens
Curr. Cancer Drug Targets
8
545-553
2008
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2
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739801
Han
Expression, crystallization an ...
Thermoplasma acidophilum
Acta Crystallogr. Sect. F
62
1127-1130
2006
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739977
Kim
Characterization of ARD1 varia ...
Homo sapiens, Mus musculus
Biochem. Biophys. Res. Commun.
340
422-427
2006
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2
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659937
Geissenhoener
Dependence of ORC silencing fu ...
Saccharomyces cerevisiae
Mol. Cell. Biol.
24
10300-10312
2004
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1
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1
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657745
Polevoda
Composition and function of th ...
Saccharomyces cerevisiae
Biochem. Biophys. Res. Commun.
308
1-11
2003
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1
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1
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1
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659263
Sugiura
An evolutionarily conserved N- ...
Mus musculus
J. Biol. Chem.
278
40113-40120
2003
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12
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12
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2
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2
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-
659935
Gautschi
The yeast Nalpha-acetyltransfe ...
Saccharomyces cerevisiae, Saccharomyces cerevisiae MH272-3f a/alpha
Mol. Cell. Biol.
23
7403-7414
2003
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740977
Ingram
Genetic manipulation indicates ...
Trypanosoma brucei, Trypanosoma brucei MiTat 427
Mol. Biochem. Parasitol.
111
309-317
2000
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11
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2
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11
1
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11
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11
1
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1
1
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-
740372
Park
ARD1 and NAT1 proteins form a ...
Saccharomyces cerevisiae
EMBO J.
11
2087-2093
1992
-
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-
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2
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1
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-
740373
Mullen
Identification and characteriz ...
Saccharomyces cerevisiae
EMBO J.
8
2067-2075
1989
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2
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1
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