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Literature summary for 2.3.1.255 extracted from

  • Ree, R.; Myklebust, L.; Thiel, P.; Foyn, H.; Fladmark, K.; Arnesen, T.
    The N-terminal acetyltransferase Naa10 is essential for zebrafish development (2015), Biosci. Rep., 35, e00249.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.255

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21 cells Danio rerio

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + DDDIAAL Danio rerio
-
 CoA + N-acetyl-DDDIAAL
-
 ?
acetyl-CoA + EEEIAAL Danio rerio best substrate CoA + N-acetyl-EEEIAAL
-
 ?
acetyl-CoA + MLGPEGG Danio rerio poor substrate CoA + N-acetyl-MLGPEGG
-
 ?
acetyl-CoA + SESSSKS Danio rerio
-
 CoA + N-acetyl-SESSSKS
-
 ?

Organism

Organism UniProt Comment Textmining
Danio rerio Q7T3B8
-
-

Purification (Commentary)

Purification (Comment) Organism
HisTrap column chromatography and Superdex 75 gel filtration Danio rerio

Source Tissue

Source Tissue Comment Organism Textmining
brain strong expression Danio rerio
-
eye strong expression Danio rerio
-
larva
-
 Danio rerio
-
additional information ubiquitous expression with especially strong staining in brain and eye Danio rerio
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + DDDIAAL
-
 Danio rerio CoA + N-acetyl-DDDIAAL
-
 ?
acetyl-CoA + DDDIAALRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-DDDIAALRWGRPVGRRRRPVRVYP
-
 ?
acetyl-CoA + EEEIAAL best substrate Danio rerio CoA + N-acetyl-EEEIAAL
-
 ?
acetyl-CoA + EEEIAALRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-EEEIAALRWGRPVGRRRRPVRVYP
-
 ?
acetyl-CoA + MLGPEGG poor substrate Danio rerio CoA + N-acetyl-MLGPEGG
-
 ?
acetyl-CoA + MLGPEGGRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-MLGPEGGRWGRPVGRRRRPVRVYP
-
 ?
acetyl-CoA + SESSSKS
-
 Danio rerio CoA + N-acetyl-SESSSKS
-
 ?
acetyl-CoA + SESSSKSRWGRPVGRRRRPVRVYP
-
 Danio rerio CoA + Nalpha-acetyl-SESSSKSRWGRPVGRRRRPVRVYP
-
 ?
additional information N-terminal EEEI is acetylated 3fold more than the DDDI substrate, which again is preferred almost 2fold to SESS, the canonical NatA substrate Danio rerio ?
-
 ?

Synonyms

Synonyms Comment Organism
ARD homolog a
-
 Danio rerio
ARD1
-
 Danio rerio
NAA10
-
 Danio rerio
Nalpha-acetyltransferase 10
-
 Danio rerio

General Information

General Information Comment Organism
malfunction naa10 morphants display increased lethality, growth retardation and developmental abnormalities like bent axis, abnormal eyes and bent tails Danio rerio
physiological function the enzyme is essential for normal development and viability of zebrafish Danio rerio