Literature summary for 2.3.1.24 extracted from

Kim, M.H.; Ahn, H.K.; Lee, E.J.; Kim, S.J.; Kim, Y.R.; Park, J.W.; Park, W.J.
Hepatic inflammatory cytokine production can be regulated by modulating sphingomyelinase and ceramide synthase 6 (2017), Int. J. Mol. Med., 39, 453-462 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q8C172	-	-

General Information

General Information	Comment	Organism
physiological function	CerS6 overexpression elevates TNFalpha secretion via p38 mitogen-activated protein kinase activation. The treatment of CerS6 overexpressing cells with palmitate synergistically increases cytokine secretion. Neither palmitate treatment nor CerS6 overexpression alter lipopolysaccharide-induced cytokine secretion	Mus musculus

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Release 2023.1 (January 2023)