Literature summary for 2.3.1.24 extracted from

Williams, B.; Correnti, J.; Oranu, A.; Lin, A.; Scott, V.; Annoh, M.; Beck, J.; Furth, E.; Mitchell, V.; Senkal, C.E.; Obeid, L.; Carr, R.M.
A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis (2018), FASEB J., 32, 130-142 .

Search for more literature for 2.3.1.24

Application

Application	Comment	Organism
medicine	isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro	Homo sapiens
medicine	isoform CerS6 is specifically upregulated in experimental alcoholic steatosis in vivo and in vitro. In vivo ceramide reduction by inhibition of de novo ceramide synthesis reduces PLIN2 and hepatic steatosis in alcohol-fed mice, and improves glucose homeostasis in control and Etoh mice, but only de novo synthesis inhibition. Inhibition of ceramide synthesis during alcohol feeding has minimal effect on body composition, food intake, and energy expenditure	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q6ZMG9	-	-
Mus musculus	Q8C172	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	-	Homo sapiens	-
HepG2-VL17A cell	human hepatoma HepG2 cells stably transfected with recombinant plasmids carrying the murine alcohol dehydrogenase gene and the human cytochrome P450 2E1 gene, in vitro model of alcoholic steatosis	Homo sapiens	-
liver	-	Mus musculus	-
liver	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Mus musculus	CerS6 is upregulated in alcoholic steatosis	up
Homo sapiens	CerS6 is upregulated in alcoholic steatosis and in response to ethanol	up

General Information

General Information	Comment	Organism
physiological function	nonspecific CerS reduction with fumonisin B1 reduces PLIN2 protein	Homo sapiens

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Release 2023.1 (January 2023)