Cloned (Comment) | Organism |
---|---|
gene CERS5, recombinant expression in HEK-293T cells, quantitative real-time quantitative PCR enzyme expression analysis | Homo sapiens |
gene CERS6, recombinant expression in HEK-293T cells, quantitative real-time quantitative PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of CerS6 by siRNA. Profiles of non-hydroxylated and 2-hydroxy-ceramides in transgenic HeLa cells expressing different CerS isozymes and or different specific interfence RNAs, overview | Homo sapiens |
additional information | profiles of non-hydroxylated and 2-hydroxy-ceramides in transgenic HeLa cells expressing different CerS isozymes and or different specific interfence RNAs, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | CerS6 lysate produces nonhydroxy-dihydro-ceramides that included strong bands for C14:0- and C16:0-dihydro-ceramide, but a weak band for C18:0-dihydro-ceramide | ? | - |
? | |
sphingosine + palmitoyl-CoA | Homo sapiens | - |
N-palmitoylsphingosine + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q6ZMG9 | - |
- |
Homo sapiens | Q8N5B7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
keratinocyte | epidermal, expression analysis of the CerS family members during keratinocyte differentiation, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate specificity, overview | Homo sapiens | ? | - |
? | |
additional information | CerS6 lysate produces nonhydroxy-dihydro-ceramides that included strong bands for C14:0- and C16:0-dihydro-ceramide, but a weak band for C18:0-dihydro-ceramide | Homo sapiens | ? | - |
? | |
sphingosine + 2-hydroxy-palmitoyl-CoA | - |
Homo sapiens | N-2-hydroxy-palmitoyl-sphingosine + CoA | - |
? | |
sphingosine + palmitoyl-CoA | - |
Homo sapiens | N-palmitoylsphingosine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase 5 | - |
Homo sapiens |
ceramide synthase 6 | - |
Homo sapiens |
CerS5 | - |
Homo sapiens |
CerS6 | - |
Homo sapiens |
LASS5 | - |
Homo sapiens |
Lass6 | - |
Homo sapiens |
longevity assurance homologue 5 | - |
Homo sapiens |
longevity assurance homologue 6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | profiles of non-hydroxylated and 2-hydroxy-ceramides in transgenic HeLa cells expressing different CerS isozymes and or different specific interfence RNAs, overview | Homo sapiens |
physiological function | differences in the expression patterns of CerS family members may play an important role in the production of the CER/2-hydroxy ceramide (CER) compositions of different chain lengths observed in different cell types and even in the altered production that occurring during keratinocyte differentiation | Homo sapiens |