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Literature summary for 2.3.1.24 extracted from

  • Mandon, E.C.; Ehses, I.; Rother, J.; van Echten, G.; Sandhoff, K.
    Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver (1992), J. Biol. Chem., 267, 11144-11148 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid
-
Mus musculus
additional information enzyme activitiy does not change by pretreating the endoplasmic reticulum-derived membrane vesicles with detergent Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum mainly, the enzyme faces the cytosolic side of the endoplasmic reticulum, so that substrates have free access to the active site Mus musculus 5783
-
Golgi membrane low enzyme level Mus musculus 139
-
vesicle membrane vesicles derived from endoplasmic reticlum and Golgi membranes, mouse liver smooth and rough ER vesicles Mus musculus 31982
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.000049
-
endoplasmic reticulum-derived membrane vesicles, pH 7.5, 37°C Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-dehydrosphinganine + palmitoyl-CoA
-
Mus musculus N-palmitoyl-3-dehydrosphinganine
-
?
sphinganine + palmitoyl-CoA
-
Mus musculus N-palmitoylsphinganine + CoA
-
?

Synonyms

Synonyms Comment Organism
SpAT
-
Mus musculus
sphinganine N-acyltransferase
-
Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
assay at Mus musculus

General Information

General Information Comment Organism
metabolism serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase are responsible for the first steps in sphingolipid biosynthesis forming 3-oxosphinganine, sphinganine, and dihydroceramide, respectively Mus musculus