Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid | - |
Mus musculus | |
additional information | enzyme activitiy does not change by pretreating the endoplasmic reticulum-derived membrane vesicles with detergent | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | mainly, the enzyme faces the cytosolic side of the endoplasmic reticulum, so that substrates have free access to the active site | Mus musculus | 5783 | - |
Golgi membrane | low enzyme level | Mus musculus | 139 | - |
vesicle | membrane vesicles derived from endoplasmic reticlum and Golgi membranes, mouse liver smooth and rough ER vesicles | Mus musculus | 31982 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.000049 | - |
endoplasmic reticulum-derived membrane vesicles, pH 7.5, 37°C | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3-dehydrosphinganine + palmitoyl-CoA | - |
Mus musculus | N-palmitoyl-3-dehydrosphinganine | - |
? | |
sphinganine + palmitoyl-CoA | - |
Mus musculus | N-palmitoylsphinganine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SpAT | - |
Mus musculus |
sphinganine N-acyltransferase | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.2 | - |
assay at | Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase are responsible for the first steps in sphingolipid biosynthesis forming 3-oxosphinganine, sphinganine, and dihydroceramide, respectively | Mus musculus |