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Literature summary for 2.3.1.24 extracted from
- Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme (1991), J. Biol. Chem., 266, 14486-14490 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fumonisin B1 | complete inhibition in vivo and in vitro | Rattus norvegicus |  |
| additional information | fumonisins isolated from Fusarium moniliforme inhibit the conversion of sphinganine to N-acyl-sphinganines and the activity of sphingosine N-acyltransferase (ceramide synthase). No inhibiton of serine palmitoyltransferase by fumonisin B1 | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sphingosine + palmitoyl-CoA | Rattus norvegicus | - |
N-palmitoylsphingosine + CoA | - |
? | |
| sphingosine + palmitoyl-CoA | Rattus norvegicus Sprague-Dawley | - |
N-palmitoylsphingosine + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
| Rattus norvegicus Sprague-Dawley | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the conversion of [14C]sphinganine to N-acyl-[14C]sphinganines | Rattus norvegicus | ? | - |
? | |
| additional information | the conversion of [14C]sphinganine to N-acyl-[14C]sphinganines | Rattus norvegicus Sprague-Dawley | ? | - |
? | |
| sphingosine + palmitoyl-CoA | - |
Rattus norvegicus | N-palmitoylsphingosine + CoA | - |
? | |
| sphingosine + palmitoyl-CoA | - |
Rattus norvegicus Sprague-Dawley | N-palmitoylsphingosine + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ceramide synthase | - |
Rattus norvegicus |
| sphingosine N-acyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0001 | - |
pH 7.4, 37°C | Rattus norvegicus | fumonisin B1 | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disruption of the de novo pathway of sphingolipid biosynthesis may be a critical in the diseases that have been associated with consumption of fumonisins. Fusarium moniliforme causes equine leucoencephalomalacia, porcine pulmonary edem syndrome, and liver cancer in rats | Rattus norvegicus |
| metabolism | the conversion of sphinganine to N-acyl-sphinganines is thought to precede via introduction of the 4,5-trans double bond of sphingosine | Rattus norvegicus |
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