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Literature summary for 2.3.1.24 extracted from

  • Choi, S.; Snider, J.M.; Olakkengil, N.; Lambert, J.M.; Anderson, A.K.; Ross-Evans, J.S.; Cowart, L.A.; Snider, A.J.
    Myristate-induced endoplasmic reticulum stress requires ceramide synthases 5/6 and generation of C14-ceramide in intestinal epithelial cells (2018), FASEB J., 32, 5724-5736 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.24

Organism

Organism UniProt Comment Textmining
Mus musculus Q8C172 isoform CerS6
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Mus musculus Q9D6K9 isoform CerS5
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Source Tissue

Source Tissue Comment Organism Textmining
epithelium
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 Mus musculus
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intestine
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 Mus musculus
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General Information

General Information Comment Organism
physiological function inhibition by fumosinin and siRNA for isoforms CerS5 or CerS6 suppresses myristate-induced C14-ceramide generation and XBP1 splicing. Increased XBP1 splicing induces the downstream expression of IL-6 in a CerS5/CerS6-dependent manner. A myristate-enriched milk fat-based diet, but not a lard-based diet, increases C14-ceramide, XBP1 splicing and IL-6 expression in vivo Mus musculus
physiological function inhibition by fumosinin and siRNA for isoforms CerS5 or CerS6 suppresses myristate-induced C14-ceramide generation and XBP1 splicing. Increased XBP1 splicing induces the downstream expression of IL-6 in a CerS5/CerS6-dependent manner. A myristate-enriched milk fat-based diet, but not a lard-based diet, increases C14-ceramide,XBP1 splicing and IL-6 expression in vivo Mus musculus