Activating Compound | Comment | Organism | Structure |
---|---|---|---|
N-(4-hydroxyphenyl)retinamide | i.e. 4-HPR or fenretinide, elevates ceramide in neuroblastoma cell lines by coordinating activation of serine palmitoyltransferase and ceramide synthase. 4-HPR treatment does not accelerate cellular decay of sphingomyelin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
fumonisin B1 | a ceramide synthase inhibitor | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphinganine + palmitoyl-CoA | Homo sapiens | - |
N-palmitoyl-DL-dihydrosphingosine + CoA | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CHLA-90 cell | - |
Homo sapiens | - |
neuroblastoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
sphinganine + palmitoyl-CoA | - |
Homo sapiens | N-palmitoyl-DL-dihydrosphingosine + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ceramide synthase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |