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Literature summary for 2.3.1.24 extracted from

  • Sridevi, P.; Alexander, H.; Laviad, E.L.; Pewzner-Jung, Y.; Hannink, M.; Futerman, A.H.; Alexander, S.
    Ceramide synthase 1 is regulated by proteasomal mediated turnover (2009), Biochim. Biophys. Acta, 1793, 1218-1227 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.24

Cloned(Commentary)

Cloned (Comment) Organism
gene CERS5, stable recombinant ectopic overexpression of N-terminally FLAG3-tagged CerS5 in HEK-293 or HeLa cells, the level of FLAG-tagged CerS5 remains constant after exposure to cisplatin, doxorubicin, or UV light Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information in HEK-293 cells, ectopically expressed murine CerS5 only sensitized cells to doxorubicin and vincristine Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sphinganine + palmitoyl-CoA Mus musculus
-
 N-palmitoylsphinganine + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9D6K9
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
sphinganine + palmitoyl-CoA
-
 Mus musculus N-palmitoylsphinganine + CoA
-
 ?

Subunits

Subunits Comment Organism
? x * 50000, recombinant FLAG3-tagged CerS5, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
ceramide synthase 5
-
 Mus musculus
CerS5
-
 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Mus musculus

General Information

General Information Comment Organism
physiological function isozyme CerS5 sensitizes cells to doxorubicin and vincristine Mus musculus