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Literature summary for 2.3.1.24 extracted from

  • Tirodkar, T.S.; Lu, P.; Bai, A.; Scheffel, M.J.; Gencer, S.; Garrett-Mayer, E.; Bielawska, A.; Ogretmen, B.; Voelkel-Johnson, C.
    Expression of ceramide synthase 6 transcriptionally activates acid ceramidase in a c-Jun N-terminal kinase (JNK)-dependent manner (2015), J. Biol. Chem., 290, 13157-13167.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression of wild-type and mutant enzymes in Escherichia coli strain BJ5183, and transient expression in HEK293A cells, HT29 cells, and SW620 cells from an adenovirus vector Mus musculus

Protein Variants

Protein Variants Comment Organism
H212A site-directed mutagenesis Mus musculus
additional information enzyme knockout by shRNA Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information no enzyme inhibition by curcumin Mus musculus
SP600125
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Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus the enzyme catalyzes the synthesis of significantly more 17C16- and 17C24:1-ceramides and significantly less 17C22:0-, 17C24:0, and 17C26:0-ceramides in vivo, analysis of sphingosine and ceramidases in different cells, overview ?
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Organism

Organism UniProt Comment Textmining
Mus musculus Q8C172
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Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
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Mus musculus
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breast
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Mus musculus
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colon
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Mus musculus
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HCT-116 cell
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Mus musculus
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head and neck squamous carcinoma cell
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Mus musculus
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intestine high expression level Mus musculus
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lung
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Mus musculus
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MCF-7 cell
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Mus musculus
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SW-480 cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the synthesis of significantly more 17C16- and 17C24:1-ceramides and significantly less 17C22:0-, 17C24:0, and 17C26:0-ceramides in vivo, analysis of sphingosine and ceramidases in different cells, overview Mus musculus ?
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?

Synonyms

Synonyms Comment Organism
ceramide synthase 6
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Mus musculus
CerS6
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Mus musculus

General Information

General Information Comment Organism
malfunction decreased enzyme expression induces endoplasmic reticulum stress and apoptosis in head and neck squamous carcinoma cells but not in A-549, MCF-7, or SW-480 cells, which are derived from lung, breast, and colon cancer, respectively, detailed overview Mus musculus
metabolism due to the highly dynamic nature of sphingolipid metabolism, alterations in the expression of CerS6 may have impacts beyond increased generation of C16-ceramide Mus musculus
physiological function activity of CerS in the salvage pathway in which sphingosine is recycled into ceramides. Upregulation of CerS6 expression increases C16-ceramide generation at the expense of very long chain ceramides. Increased expression of acid ceramidase in response to CerS6 expression occurs via a JNK-AP1-dependent mechanism and is important for survival. Enzyme CerS6 may transcriptionally activate the expression of acid ceramidase (ASAH1) Mus musculus