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Literature summary for 2.3.1.23 extracted from

  • Akagi, S.; Kono, N.; Ariyama, H.; Shindou, H.; Shimizu, T.; Arai, H.
    Lysophosphatidylcholine acyltransferase 1 protects against cytotoxicity induced by polyunsaturated fatty acids (2016), FASEB J., 30, 2027-2039 .
    View publication on PubMed
Search for more literature for 2.3.1.23

Cloned(Commentary)

Cloned (Comment) Organism
LPCAT1, quantitative real-time PCR expression analysis Mus musculus
LPCAT1, quantitative real-time PCR expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information construction of LPCAT1 knockout HeLa cells Homo sapiens
additional information construction of LPCAT1 knockout mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NF37
-
-
Mus musculus Q3TFD2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
COS-7 cell
-
 Homo sapiens
-
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
Huh-7 cell
-
 Homo sapiens
-
L-929 cell
-
 Homo sapiens
-
retina enzyme LPCAT1 quantitative real-time PCR expression analysis Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine quantification of palmitic acid by gas chromatography Mus musculus CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
-
 ?
palmitoyl-CoA + 1-palmitoyl-lysophosphatidylcholine quantification of palmitic acid by gas chromatography Homo sapiens CoA + 1,2-dipalmitoyl-lysophosphatidylcholine
-
 ?

Synonyms

Synonyms Comment Organism
LPCAT1
-
 Mus musculus
LPCAT1
-
 Homo sapiens
lysophosphatidylcholine acyltransferase 1
-
 Mus musculus
lysophosphatidylcholine acyltransferase 1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mus musculus
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Mus musculus
6.8
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction LPCAT1 knockdown enhances polyunsaturated fatty acids (PUFAs)-induced cytotoxicity. In LPCAT1 knockout mice, DPPC level is reduced and UPR is activated in the retina. In a study of rd11 mice in which there is a natural loss-of-function of LPCAT1, the level of DPPC in the retina is decreased, resulting in retinal degeneration Mus musculus
malfunction LPCAT1 knockdown enhances polyunsaturated fatty acids (PUFAs)-induced cytotoxicity. Transfection of an siRNA against LPCAT1 efficiently reduces protein expression of LPCAT1 in HeLa cells. LPCAT1 knockdown cells show a significant reduction in the amount of DPPC upon eicosapentaenoic acid (EPA; 20:5) treatment compared with siControl-transfected cells, whereas the amounts of EPA-containing species are not affected by LPCAT1 knockdown. Oleic acid treatment has no effect Homo sapiens
physiological function fatty acyl chains of membrane phospholipids are regulated by various lysophospholipid acyltransferases (LPLATs). Cells respond to loading with excess polyunsaturated fatty acids (PUFAs), such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. Dipalmitoylphosphatidylcholine (DPPC) is increased after the production of PUFA-containing phospholipids in cells loaded with PUFAs. An RNA interference screen of lipid-metabolizing enzymes reveals that lysophosphatidylcholine acyltransferase 1 (LPCAT1) is involved in the DPPC production, overview. Dipalmitoylphosphatidylcholine (DPPC) is produced via LPCAT1 to protect against excess PUFA-induced cytotoxicity Homo sapiens
physiological function fatty acyl chains of membrane phospholipids are regulated by various lysophospholipid acyltransferases (LPLATs). Cells respond to loading with excess polyunsaturated fatty acids (PUFAs), such as arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. Dipalmitoylphosphatidylcholine (DPPC) is increased after the production of PUFA-containing phospholipids in cells loaded with PUFAs. In murine retina, in which PUFAs are highly enriched, DPPC is produced along with increase of PUFA-containing phospholipids. Dipalmitoylphosphatidylcholine (DPPC) is produced via LPCAT1 to protect against excess PUFA-induced cytotoxicity Mus musculus