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Literature summary for 2.3.1.225 extracted from

  • Sharma, C.; Wang, H.X.; Li, Q.; Knoblich, K.; Reisenbichler, E.S.; Richardson, A.L.; Hemler, M.E.
    Protein acyltransferase DHHC3 regulates breast tumor growth, oxidative stress, and senescence (2017), Cancer Res., 77, 6880-6890 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.225

Application

Application Comment Organism
medicine DHHC3 is upregulated in malignant and metastatic human breast cancer. Elevated expression of DHHC3 correlates with diminished patient survival in breast cancer and six other human cancer types. DHHC3 ablation in human MDA-MB-231 mammary tumor cell xenografts reduces the sizes of both the primary tumor and metastatic lung colonies. Increased oxidative stress and senescence is observed in DHHC3-ablated cells. DHHC3-ablated tumors also show enhanced recruitment of innate immune cells associated with clearance of senescent tumors. Concomitant ablation of the upregulated oxidative stress protein TXNIP substantially negates the effects of DHHC3 depletion on oxidative stress and senescence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NYG2
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Source Tissue

Source Tissue Comment Organism Textmining
BT-474 cell
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 Homo sapiens
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BT-549 cell
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 Homo sapiens
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HEK-293 cell
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 Homo sapiens
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MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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ZR-75 cell
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 Homo sapiens
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Synonyms

Synonyms Comment Organism
DHHC3
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 Homo sapiens
ZDHHC3
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 Homo sapiens