Application | Comment | Organism |
---|---|---|
analysis | development of a MGAT enzymatic assay of human intestinal microsomes using a high-throughput mass spectrometry-based detection system | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-(4-chlorophenoxy)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methylphenyl]acetamide | potent inhibitory activity toward human intestinal MGAT and recombinant human MGAT2, with selectivity over MGAT3. IC50 value in intestinal microsomes 0.000021 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q3SYC2 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
intestine | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
oleoyl-CoA + 2-oleoylglycerol | - |
Homo sapiens | CoA + 1,2-dioleoylglycerol | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000083 | - |
pH 7.5, 23°C | Homo sapiens | 2-(4-chlorophenoxy)-N-[5-[(4-methoxyphenyl)sulfamoyl]-2-methylphenyl]acetamide |