Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q91ZV4 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
MOGAT1 | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | basal and fasting-induced expression of Mogat1 is markedly diminished in the liver of mice lacking the transcription factor PPARalpha | down |
Mus musculus | hepatic expression of Mogat1 is significantly increased in the liver of fasted mice compared with mice given ad libitum access to food | up |
General Information | Comment | Organism |
---|---|---|
physiological function | hepatic expression of Mogat1 is significantly increased in the liver of fasted mice compared with mice given ad libitum access to food. Basal and fasting-induced expression of Mogat1 is markedly diminished in the liver of mice lacking the transcription factor PPARalpha. Suppressing Mogat1 expression in liver and adipose tissue with antisense oligonucleotides reduces hepatic MGAT activity and triglyceride content compared with fasted controls. The expression of many other PPARalpha target genes and PPARalpha activity is also decreased in mice given Mogat1 antisense oligonucleotides | Mus musculus |