Literature summary for 2.3.1.216 extracted from

Watanabe, K.; Praseuth, A.P.; Wang, C.C.
A comprehensive and engaging overview of the type III family of polyketide synthases (2007), Curr. Opin. Chem. Biol., 11, 279-286.

Search for more literature for 2.3.1.216

Application

Application	Comment	Organism
molecular biology	use of pentaketide chromone synthase for rational biosynthetic engineering to generate molecular diversity and pursue innovative, biologically potent compounds	Aloe arborescens

Protein Variants

Protein Variants	Comment	Organism
M197G	site-directed mutagenesis, the mutant enzyme shows altered activity compared to the wild-type enzyme producing SEK4/SEK4b like oktaketide synthase	Aloe arborescens

Organism

Organism	UniProt	Comment	Textmining
Aloe arborescens	-	single gene	-

Synonyms

Synonyms	Comment	Organism
PCS	-	Aloe arborescens
pentaketide chromone synthase	-	Aloe arborescens

General Information

General Information	Comment	Organism
evolution	pentaketide chromone synthase is a plant-specific type III polyketide synthase that belongs to the chalcone synthase superfamily of type III polyketide synthases	Aloe arborescens
additional information	active site structure of wild-type and mutant enzymes, overview. Amino acid residue at position 197 in the active site governs the chain length of the polyketide. Leucine at position 256 in the active site for both oktaketide synthase and pentaketide chromone synthase influences the substrate preference for malonyl-CoA as a starting unit, while a glycine residue located in the same position and found in the catalytic pocket of chalcone synthase can possibly compel the enzyme to readily accept 4-coumaroyl-CoA as a starting unit	Aloe arborescens

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Release 2023.1 (January 2023)