Literature summary for 2.3.1.21 extracted from

Jernberg, J.N.; Bowman, C.E.; Wolfgang, M.J.; Scafidi, S.
Developmental regulation and localization of carnitine palmitoyltransferases (CPTs) in rat brain (2017), J. Neurochem., 142, 407-419 .

Search for more literature for 2.3.1.21

Inhibitors

Inhibitors	Comment	Organism	Structure
etomoxir	regional differences in brain fatty acid oxidation may be blocked by irreversible CPT1a inhibitor etomoxir; regional differences in brain fatty acid oxidation may be blocked by irreversible CPT1a inhibitor etomoxir	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P18886	isoform CPT2	-
Rattus norvegicus	P32198	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	isoforms CPT1a and CPT2 are expressed exclusively by astrocytes	Rattus norvegicus	-
brain	brain isoform CPT1a RNA and total protein expression are unchanged throughout post-natal development (PND0, PND7, PND14, PND21 and PND50). Acylcarnitines, generated by CPT1a, significantly increase with age and peak at PND21 in all brain regions, concurrent with the increased expression of enzymes involved in mitochondrial beta-oxidation	Rattus norvegicus	-
brain	brain isoform CPT2 RNA peaks at post-natal day 21 and remains unchanged through post-natal day 50 in all regions studied. CPT2 transcript abundance is highly developmentally regulated in the cortex, midbrain, and cerebellum, and significantly increases with age. The peak of acylcarnitine abundance in all brain regions profiled at post-natal day 21 corresponds to the maximal expression of CPT2 mRNA	Rattus norvegicus	-
hippocampus	expression of isoforms CPT1a and CPT2 increases during brain development and is enriched in hippocampus relative to the cortex, midbrain, and cerebellum	Rattus norvegicus	-
hippocampus	no age differences are detected in CPT2 mRNA expression in hippocampus	Rattus norvegicus	-

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Release 2023.1 (January 2023)