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Literature summary for 2.3.1.21 extracted from

  • Pucci, S.; Zonetti, M.J.; Fisco, T.; Polidoro, C.; Bocchinfuso, G.; Palleschi, A.; Novelli, G.; Spagnoli, L.G.; Mazzarelli, P.
    Carnitine palmitoyl transferase-1A (CPT1A): a new tumor specific target in human breast cancer (2016), Oncotarget, 12, 19982-19996.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Application

Application Comment Organism
medicine overexpression of the enzyme correlates with a poor overall survival of ovarian cancer patients. CPT1A is a prognostic biomarker and rational target for therapeutic intervention of cancer Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P50416
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAOV-3 cell
-
 Homo sapiens
-
ovarian cancer cell
-
 Homo sapiens
-
ovarian serous carcinoma cell
-
 Homo sapiens
-
OVCA-432 cell
-
 Homo sapiens
-
OVCAR-3 cell
-
 Homo sapiens
-
SKOV-3 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?

Synonyms

Synonyms Comment Organism
carnitine palmitoyl transferase-1A
-
 Homo sapiens
CPT1A
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme inactivation inhibits cell growth and ATP production and decreases tumorigenicity of ovarian cancer cells in severe combined immunodeficiency mice Homo sapiens
physiological function ovarian cancer cells depend on or are addicted to enzyme-mediated fatty acid beta-oxidation for cell cycle progression Homo sapiens