Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arachidonic acid | the enzymatic activity significantly declines by treatment with 0.1 mM for 1 h | Homo sapiens | |
H2O2 | the enzymatic activity significantly and reversibly declines by 1 mM H2O2 | Homo sapiens | |
malonyl CoA | a physiological CPT1 inhibitor | Homo sapiens | |
rotenone | the enzymatic activity significantly declines by treatment with 0.001 mM for 2 h | Homo sapiens | |
tumor necrosis factor-alpha | the enzymatic activity significantly declines by treatment with 25 ng/ml for 30 min | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-carnitine | Homo sapiens | - |
CoA + L-palmitoylcarnitine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
GM03440 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase-1 | - |
Homo sapiens |
CPT1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mitochondrial CPT1 proteins are targeted for inactivation by diverse oxidants or oxidative stress in human cells | down |
General Information | Comment | Organism |
---|---|---|
metabolism | arnitine palmitoyltransferase-1 is the critical enzyme for mitochondrial beta-oxidation of long-chain fatty acids | Homo sapiens |