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Literature summary for 2.3.1.21 extracted from

  • Setoyama, D.; Fujimura, Y.; Miura, D.
    Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells (2013), Genes Cells, 18, 1107-1119.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
arachidonic acid the enzymatic activity significantly declines by treatment with 0.1 mM for 1 h Homo sapiens
H2O2 the enzymatic activity significantly and reversibly declines by 1 mM H2O2 Homo sapiens
malonyl CoA a physiological CPT1 inhibitor Homo sapiens
rotenone the enzymatic activity significantly declines by treatment with 0.001 mM for 2 h Homo sapiens
tumor necrosis factor-alpha the enzymatic activity significantly declines by treatment with 25 ng/ml for 30 min Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
palmitoyl-CoA + L-carnitine Homo sapiens
-
CoA + L-palmitoylcarnitine
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
GM03440 cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
Hep-G2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
palmitoyl-CoA + L-carnitine
-
Homo sapiens CoA + L-palmitoylcarnitine
-
?

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase-1
-
Homo sapiens
CPT1
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens mitochondrial CPT1 proteins are targeted for inactivation by diverse oxidants or oxidative stress in human cells down

General Information

General Information Comment Organism
metabolism arnitine palmitoyltransferase-1 is the critical enzyme for mitochondrial beta-oxidation of long-chain fatty acids Homo sapiens