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Literature summary for 2.3.1.21 extracted from

  • Kuhajda, F.P.; Ronnett, G.V.
    Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity (2007), Curr. Opin. Investig. Drugs, 8, 312-317.
    View publication on PubMed
Search for more literature for 2.3.1.21

Activating Compound

Activating Compound Comment Organism Structure
C-75 i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, regulatory effects, overview Homo sapiens
C-75 i.e. 3-carboxy-4-alkyl-2-methylenebutyrolactone, physiologic enzyme stimulation, the stimulation reduces food consumption and weight, regulatory effects, overview Rattus norvegicus

Application

Application Comment Organism
medicine enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
etomoxir
-
 Homo sapiens
malonyl-CoA has a regulatory role in vivo Homo sapiens
malonyl-CoA has a regulatory role in vivo Rattus norvegicus
additional information enzyme inhibitors are used to shift the heart's reliance away from fatty acid oxidation to glucose as energy source to increase cardiac efficiency, overview Homo sapiens
oxfenicine
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
 Homo sapiens 5741
-
mitochondrial outer membrane
-
 Rattus norvegicus 5741
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
88200
-
 x * 88200, isozymes L-CPT1 and M-CPT1 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview ?
-
 ?
additional information Homo sapiens the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview ?
-
 ?
palmitoyl-CoA + L-carnitine Homo sapiens
-
 CoA + L-palmitoylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-palmitoylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes L-CPT1 and M-CPT1
-
Rattus norvegicus
-
 isozymes L-CPT1 and M-CPT1
-

Source Tissue

Source Tissue Comment Organism Textmining
liver isozyme L-CPT-1 Homo sapiens
-
liver isozyme L-CPT-1 Rattus norvegicus
-
muscle isozyme M-CPT-1 Homo sapiens
-
muscle isozyme M-CPT-1 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, inhibition of fatty acid oxidation increases food intake, overview Rattus norvegicus ?
-
 ?
additional information the enzyme is rate-limiting in the mitochondrial fatty axid oxidation pathway, physiologic regulation, overview Homo sapiens ?
-
 ?
palmitoyl-CoA + L-carnitine
-
 Homo sapiens CoA + L-palmitoylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-palmitoylcarnitine
-
 ?

Subunits

Subunits Comment Organism
? x * 88200, isozymes L-CPT1 and M-CPT1 Homo sapiens

Synonyms

Synonyms Comment Organism
carnitine palmitoyltransferase-1
-
 Homo sapiens
carnitine palmitoyltransferase-1
-
 Rattus norvegicus
CPT-1
-
 Homo sapiens
CPT-1
-
 Rattus norvegicus