Literature summary for 2.3.1.21 extracted from

Lin, X.; Odle, J.
Changes in kinetics of carnitine palmitoyltransferase in liver and skeletal muscle of dogs (Canis familiaris) throughout growth and development (2003), J. Nutr., 133, 1113-1119.

Search for more literature for 2.3.1.21

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	the apparent KM-value in liver increases from birth to 3 weeks and then decreases and remains constant after 6 weeks of age. The highest Km-value is in 3-week old dogs and is about 50% greater than in older dogs. The apparent Km-value for carnitine measured in muscle is relatively constant in dogs of all ages tested. The apparent KM-for carnitine is 27% lower in muscle than in liver. Carnitine may have an important role in the regulation of fatty acid oxidation and incrrased dietary carnitine may improve fatty acid oxidative capacity in developing dogs	Canis lupus familiaris

Organism

Organism	UniProt	Comment	Textmining
Canis lupus familiaris	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	activity is low at birth, increases by 100% during the suckling period and declines after weaning to adult levels	Canis lupus familiaris	-
skeletal muscle	activity continues to increase with age, reaching adult levels after 9 weeks. Concentration in adult is 10fold the apparent Km-value for carnitine	Canis lupus familiaris	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
palmitoyl-CoA + L-carnitine	-	Canis lupus familiaris	CoA + L-palmitoylcarnitine	-	?

Synonyms

Synonyms	Comment	Organism
CPT	-	Canis lupus familiaris

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Release 2023.1 (January 2023)