Cloned (Comment) | Organism |
---|---|
mutant enzymes expressed in Pichia pastoris | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
DELTA563-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA659-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA728-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA752-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA762-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA763-772 | mitochondria from Pichia pastoris expressing the deletion mutant have no CPTI activity | Homo sapiens |
DELTA766-772 | activity of the mutant is similar to wild-type enzyme | Homo sapiens |
DELTA769-772 | activity of the mutant is similar to wild-type enzyme | Homo sapiens |
L264A | 60.4% of the wild-type activity | Homo sapiens |
L764R | 16.3% of the wild-type activity | Homo sapiens |
L764V | as active as the wild-type enzyme | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0448 | - |
palmitoyl-CoA | mutant enzyme L764R | Homo sapiens | |
0.0466 | - |
palmitoyl-CoA | wild-type enzyme | Homo sapiens | |
0.679 | - |
L-carnitine | wild-type enzyme | Homo sapiens | |
1.588 | - |
L-carnitine | mutant enzyme L764R | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q92523 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
palmitoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + L-palmitoylcarnitine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carnitine palmitoyltransferase I | - |
Homo sapiens |
M-CPTI | - |
Homo sapiens |