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Literature summary for 2.3.1.21 extracted from

  • Stephens, T.W.; Cook, G.A.; Harris, R.A.
    Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I (1983), Biochem. J., 212, 521-524.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
malonyl-CoA CPT I; inhibition is very pH-dependent: malonyl-CoA concentrations causing 50% inhibition at pH 6.0, 6.5, 7.0, 7.5 and 8.0 are 0.00004, 0.001, 0.009, 0.04 and 0.2 mM, respectively Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial inner membrane inner face of inner membrane Rattus norvegicus 5743
-
mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Rattus norvegicus
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + L-carnitine
-
 Rattus norvegicus CoA + L-acylcarnitine
-
 ?