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Literature summary for 2.3.1.21 extracted from

  • Ramsay, R.R.; Derrick, J.P.; Friend, A.S.; Tubbs, P.K.
    Purification and properties of the soluble carnitine palmitoyltransferase from bovine liver mitochondria (1987), Biochem. J., 244, 271-278.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.21

Inhibitors

Inhibitors Comment Organism Structure
11-trimethylamino-undecanoyl-DL-carnitine
-
 Bos taurus
2-bromoacetyl-CoA
-
 Bos taurus
2-bromopalmitoyl-CoA
-
 Bos taurus
2-[5(4-chlorophenyl)pentyl]-oxirane-2-carboxyl-CoA
-
 Bos taurus
bromoacetyl-CoA
-
 Bos taurus
malonyl-CoA
-
 Bos taurus
Tween 20
-
 Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information
-
 Bos taurus
0.0008
-
 palmitoyl-CoA with C8-CoA Bos taurus
0.0009
-
 decanoyl-CoA
-
 Bos taurus
0.0012
-
 myristoyl-CoA
-
 Bos taurus
0.0017
-
 stearoyl-CoA
-
 Bos taurus
0.0018
-
 hexanoyl-CoA
-
 Bos taurus
0.004
-
 dodecanoyl-CoA
-
 Bos taurus
0.0051
-
 butyryl-CoA
-
 Bos taurus
0.022
-
 acetyl-CoA
-
 Bos taurus
0.108
-
 L-carnitine with C8-CoA Bos taurus
0.12
-
 L-carnitine with C12-CoA Bos taurus
0.185
-
 L-carnitine with C16-CoA Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
additional information
-
 amino acid composition Bos taurus
63500
-
 gel filtration, sucrose density gradient sedimentation Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + L-carnitine Bos taurus
-
 CoA + L-acylcarnitine
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 ox
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Reaction

Reaction Comment Organism Reaction ID
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine rapid-equilibrium random-order mechanism Bos taurus
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acetylcarnitine
-
 ?
acyl-CoA + L-carnitine
-
 Bos taurus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine substrate specificity Bos taurus CoA + L-acylcarnitine
-
 ?
acyl-CoA + L-carnitine substrate specificity Bos taurus CoA + L-acylcarnitine
-
 r
butyryl-CoA + L-carnitine
-
 Bos taurus CoA + L-butyrylcarnitine
-
 ?
decanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-decanoylcarnitine
-
 ?
hexanoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-hexanoylcarnitine
-
 ?
lauroyl-CoA + L-carnitine
-
 Bos taurus CoA + L-lauroylcarnitine
-
 ?
myristoyl-CoA + L-carnitine best substrate Bos taurus CoA + L-myristoylcarnitine
-
 ?
palmitoyl-CoA + L-carnitine best substrate Bos taurus CoA + L-palmitoylcarnitine
-
 r
stearoyl-CoA + L-carnitine
-
 Bos taurus CoA + L-stearoylcarnitine
-
 ?

Subunits

Subunits Comment Organism
monomer 1 * 63500, SDS-PAGE Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
 pI: 6.0 Bos taurus
6 8.5
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00066
-
 2-bromopalmitoyl-CoA
-
 Bos taurus
0.17
-
 malonyl-CoA
-
 Bos taurus
0.2
-
 11-trimethylamino-undecanoyl-DL-carnitine
-
 Bos taurus
0.9
-
 2-bromoacetyl-CoA
-
 Bos taurus