Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphatidylcholine | - |
Mus musculus | |
phosphatidylethanolamine | - |
Mus musculus | |
phosphatidylinositol | - |
Mus musculus | |
phosphatidylserine | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
acyl-CoA + 1,2-diacyl-sn-glycerol | Mus musculus | isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol | CoA + triacylglycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 1,2-diacetyl-sn-glycerol | - |
Mus musculus | CoA + triacetylglycerol | - |
? | |
acyl-CoA + 1,2-diacyl-sn-glycerol | isoforms DGAT1 and DGAT2 Can compensate for each other to synthesize triacylglycerol | Mus musculus | CoA + triacylglycerol | - |
? | |
oleoyl-CoA + 1,2-dioleoyl-sn-glycerol | - |
Mus musculus | CoA + trioleoylglycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acyl-CoA:diacylglycerol acyltransferase 1 | - |
Mus musculus |
acyl-CoA:diacylglycerol acyltransferase 2 | - |
Mus musculus |
DGAT1 | - |
Mus musculus |
DGAT2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | Isoform DGAT1 inactivation promotes large lipid droplet formation. Inhibition of isoform DGAT2 augments fatty acid oxidation, whereas inhibition of DGAT1 increases triacylglycerol secretion. Triacylglycerol secretion is significantly reduced on DGAT2 inhibition without altering extracellular apolipoprotein B levels | Mus musculus |
metabolism | the triacylglycerol pool generated by DGAT1 is preferentially used for supplying substrates for oxidation, whereas DGAt2-derived triacylglycerol is more favored for secretion | Mus musculus |