Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)hex-4-en-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one | IC50: 0.0098 mM | Rattus norvegicus | |
(2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine | IC50: 0.0298 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | |
dehydropipernonaline | noncompetitive inhibition, IC50: 0.0212 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | |
additional information | inhibition mechanism, the inhibitory activity of Piper fruits is influenced by the presence of the piperidine group rather than by isobutyl group, overview | Rattus norvegicus | |
oleoyl-CoA | substrate inhibition | Rattus norvegicus | |
pipernonaline | IC50: 0.0372 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | |
piperrolein B | IC50: 0.0201 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | |
retrofractamide C | IC50: 0.9 mM, above, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0046 | - |
oleoyl-CoA | pH 8.0, 25°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
DGAT | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Rattus norvegicus | |
0.0054 | - |
oleoyl-CoA | pH 8.0, 25°C | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0098 | - |
IC50: 0.0098 mM | Rattus norvegicus | (2E)-1-[2,4-dihydroxy-6-methoxy-3-[(2R)-5-methyl-2-(1-methylethenyl)hex-4-en-1-yl]phenyl]-3-(2,4-dihydroxyphenyl)prop-2-en-1-one | |
0.0201 | - |
IC50: 0.0201 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | piperrolein B | |
0.0212 | - |
noncompetitive inhibition, IC50: 0.0212 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | dehydropipernonaline | |
0.0298 | - |
IC50: 0.0298 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine | |
0.0372 | - |
IC50: 0.0372 mM, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | pipernonaline | |
0.9 | - |
IC50: 0.9 mM, above, isolated from the extracts of fruits of Piper longum and Piper nigrum | Rattus norvegicus | retrofractamide C |