Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid | IC50: 0.0443 mM | Rattus norvegicus | |
brachynereolide | IC50: 0.25 mM, above | Rattus norvegicus | |
crepidiaside C | IC50: 0.25 mM, above | Rattus norvegicus | |
cryptotanshinone | IC50: 0.0273 mM | Rattus norvegicus | |
germanicol acetate | IC50: 0.25 mM, above | Rattus norvegicus | |
ixerin Y | IC50: 0.25 mM, above | Rattus norvegicus | |
methyl ursolate | IC50: 0.0264 mM | Rattus norvegicus | |
additional information | an ethylacetic extract of Youngia koidzumiana, a plant endemic to the Mount Chiri region of Korea, significantly inhibits the liver microsome enzyme | Rattus norvegicus | |
oleanolic acid | IC50: 0.0317 mM | Rattus norvegicus | |
sesquiterpenoids | weak inhibition | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus | - |
male sprague-dawley rats | - |
Purification (Comment) | Organism |
---|---|
native enzyme partially by microsome preparation | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1,2-dioleoyl-sn-glycerol + palmitoyl-CoA | - |
Rattus norvegicus | 1,2-dioleoyl-3-palmitoyl-sn-glycerol + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DGAT | - |
Rattus norvegicus |
diacylglycerol acyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0264 | - |
IC50: 0.0264 mM | Rattus norvegicus | methyl ursolate | |
0.0273 | - |
IC50: 0.0273 mM | Rattus norvegicus | cryptotanshinone | |
0.0317 | - |
IC50: 0.0317 mM | Rattus norvegicus | oleanolic acid | |
0.0443 | - |
IC50: 0.0443 mM | Rattus norvegicus | (2alpha,3beta)-2,3-dihydroxyurs-12-en-28-oic acid | |
0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | brachynereolide | |
0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | ixerin Y | |
0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | crepidiaside C | |
0.25 | - |
IC50: 0.25 mM, above | Rattus norvegicus | germanicol acetate |